Mechanical memory and dosing influence stem cell fate
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چکیده
منابع مشابه
Mechanical memory and dosing influence stem cell fate
We investigated whether stem cells remember past physical signals and whether these can be exploited to dose cells mechanically. We found that the activation of the Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) as well as the pre-osteogenic transcription factor RUNX2 in human mesenchymal stem cells (hMSCs) cultured on soft poly(ethylene glycol) (PEG)...
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ژورنال
عنوان ژورنال: Nature Materials
سال: 2014
ISSN: 1476-1122,1476-4660
DOI: 10.1038/nmat3889